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KMID : 1025520210630030593
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Journal of Animal Science and Technology
2021 Volume.63 No. 3 p.593 ~ p.602
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Short Communication: Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk
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Yun Bo-Hyun
Kim Young-Hoon
Park Dong-June
Oh Sang-Nam
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Abstract
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Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and functional importance of milk-derived miRNAs are still undetermined. This study applied RNA sequencing to explore the featured profiles of miRNA expression in colostrum and mature milk-originated exosomes from human, bovine, and caprine milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine and caprine milk. Interestingly, abundant miRNAs expressed in human milk are similarly conserved across species. In addition, we confirmed that immune- related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed in the colostrum and mature milk of cows and caprines as well as humans. Our results provide new insights and resources for investigating the functionality of immune-associated miRNAs and evaluating physiological and biological condition in human, bovine and caprine milk as biomarkers.
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KEYWORD
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Colostrum, Mature milk, Dietary exosome, MicroRNA, Mammals
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